For 20 years, UPMC Italy has been managing ISMETT, a government-approved research hospital (called IRCSS – Istituto di Ricovero e Cura a Carattere Scientifico), and center of excellence for organ transplantation and highly specialized therapies.ISMETT, established in Palermo in 1997 as an experimental management project promoted by the Region of Sicily and UPMC, is part of Sicily’s regional public health system. ISMETT offers all solid organ transplant programs (liver, kidney, pancreas, heart, and lung) also from living donors, and its outcomes are in line with the top international centers.

ISMETT has a total of 78 beds, 4 operating rooms and 8 beds in the day hospital units. Since the very first liver transplant performed in Sicily, in 1999, over 2,000 transplants have been performed at ISMETT.

ISMETT offers top-level patient care and contributes to developing future health care through clinical and management innovation, research, and commitment to theoretical and hands-on training offered to all clinicians.

In addition to UPMC, ISMETT collaborates with the most important Italian and international research centers, including collaborative projects with national research groups, international research groups, industries, NGOs, and other organizations.

ISMETT is the first hospital in Southern Italy to receive Joint Commission International (JCI) accreditation, an advanced accreditation system that assesses the quality and safety of hospital facilities. JCI accreditation confirms ISMETT’s top standards of patient care and patient safety, as well as an ongoing commitment to continuous improvement. Yearly training programs ensure our nurses, physicians, technicians, and administrators meet the highest quality standards in clinical care.

Within ISMETT is the Fiandaca Simulation Center, established in 2007 thanks to the Renato Fiandaca Foundation, ISMETT, and UPMC. The Center uses simulators to train clinical and non-clinical staff (e.g., 911 personnel, firemen, army forces) in individual and teamwork in emergencies, with the purpose of reducing medical errors, improving quality standards of care, and providing a safer environment for patients.

The Peter M. Winter Institute for Simulation, Education, and Research (WISER) in Pittsburgh, one of the most renowned centers of its kind in terms of experience and scientific relevance, was instrumental in opening the Renato Fiandaca Simulation Center.

Fondazione Ri.Med

The Ri.MED Foundation was established in 2006 thanks to an international partnership between the Italian Government, the Region of Sicily, the Italian National Research Council (CNR), the University of Pittsburgh, and UPMC.
The objective of Ri.MED is to promote, support, and implement biotechnology and biomedicine research projects, and rapidly translate innovative results into clinical practice.

Ri.MED pursues its mission by:

  • Spreading the role of biotechnology in the progress of humanity;
  • Training staff in specific skills in the field of biotechnology;
  • Establishing and managing biotechnology research laboratories;

In Carini, near Palermo, Ri.MED is currently involved in the realization of the Biomedical Research and Biotechnology Center (BRBC), which will become a center of reference for researchers worldwide, placing Sicily in the forefront of the biotechnology and biomedical research fields.

UPMC San Pietro FBF – Advanced Radiotherapy Center

In collaboration with San Pietro Fatebenefratelli Hospital in Rome, in 2013, UPMC Italy created UPMC San Pietro FBF Advanced Radiotherapy Center, a brand new facility that offers innovative radiotherapy treatments and stereotactic radiosurgery with oncology protocols for advanced-level care. In 2017 the Center has successfully achieved accreditation from the Joint Commission International (JCI). This recognition is based on an extensive review of the center’s patient safety and quality standards and processes. The UPMC oncology network, UPMC Hillman Cancer Center, includes 50 oncology centers in the U.S. and Europe, with top standards of care, and over 74,000 patients a year. All the oncology centers of the UPMC Hillman Cancer Center network are partners of the of the University of Pittsburgh Cancer Institute (UPCI), which has produced more than 4,500 studies in the last five years, and received $146 million in research funding in 2013 alone. This partnership ensures that each center of the UPMC network is involved in research initiatives for continual improvement in treatment techniques.

UPMC Institute for Health Chianciano Terme

In 2014, in Chianciano Terme (Tuscany), UPMC Italy created the UPMC Institute for Health, an advanced and integrated center for preventive medicine, with a special focus on (primary and secondary) metabolic syndrome, liver chronic diseases, and cardiovascular diseases. The Center offers innovative and customized screening programs, laboratory and imaging tests (EKG, elastometry, ultrasound), specialty consults (hepatology, cardiology, diabetology, dermatology, psychology, nutritional programs), digestive endoscopy services (gastroscopy, colonoscopy, video colonoscopy capsule) and innovative procedures (Endobarrier®, a new treatment for type 2 diabetes and obesity). The Center has also established an innovative and highly specialized facility for exercise and rehabilitation offering personalized physical activity plans for the prevention of cardiovascular, hepatic, and metabolic diseases.

Salvator Mundi International Hospital | UPMC

In 2017 UPMC became partner (50%) of the Salvator Mundi International Hospital (SMIH) in Rome.

UPMC co-manages the Hospital and carries out investments and collaborations in the field of private health care that will benefit Italian and foreign patients, with the goal to enhance and expand the offer across multiple specialties (e.g., oncology, orthopedics, ophthalmology, physiotherapy, rehabilitation, plastic surgery), using new technologies and innovative approaches such as, for example, regenerative medicine. In particular, an integrated Oncology Center will be created and linked to the UPMC Cancer Center network. In line with the professional experience of the two partners, the plan is to launch new programs and to improve the existing ones, including thoracic and abdominal minimally invasive surgical oncology, interventional radiology, and oncology interventional digestive endoscopy. The oncology clinical offer will be complemented by immuno-oncology therapies and a new oncology genomics service, indispensable to support therapeutic decisions with a personalized medicine approach. All aspects related to the prevention and early diagnosis of oncological diseases will also be developed, and a new dedicated program of Integrative Medicine in Oncology, one of the first in Europe, will be launched. The program will be managed by a team of physicians and experts, and will support patients and their families, helping them manage the symptoms of the disease and the side effects of the therapies.

Salvator Mundi International Hospital |UPMC was founded in 1951 and is located in the center of Rome, (Monteverde area). It has 75 beds, it manages over 2,400 admissions a year, and has about 150 employees (excluding the physicians) in addition to consulting physicians of various specialties.

Where we are

Find our medical centers in Italy (Sicily, Lazio, Tuscany)


The Italian division of the University of Pittsburgh Medical Center with facilities in Rome (UPMC San Pietro FBF, oncology radiotherapy and Salvator Mundi International Hospital UPMC |UPMC), Palermo (ISMETT IRCCS, organ transplants and highly specialized therapies and Ri.MED Foundation, research).


UPMC is an integrated global health enterprise headquartered in Pittsburgh, Pennsylvania. With its clinical, training, research, and managerial knowledge and expertise, UPMC is one of the leading health systems in the United States.


UPMC International offers a full range of health care consulting and management services focused on sharing our clinical, technological and managerial knowledge and expertise with partners around the world, customizing solutions so that patients and regions benefit and thrive.

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